Potential Long-Term Toxic Effects in Children Treated for Acute Lymphoblastic Leukemia

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Abstract
To the Editor: Successful treatment of children with acute lymphocytic leukemia raises the issue of potential long-term toxic effects, such as those addressed in the July 20 issue.1 2 3 Members of the Children's Cancer Study Group have been assessing the effect of previous treatment on the lives of such patients who survive for many years. The study group recently completed a follow-up of 9720 patients with acute lymphoblastic leukemia (ALL) who have been treated in trials conducted by the group since 1972.4 In this cohort, representing more than 43,000 person-years of follow-up, with more than 2400 patients followed for seven years . . .