Adrenocorticotropin 57, Synthesis and biological activity of ostrich and turkey hormones*
- 12 January 1984
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 23 (1) , 42-46
- https://doi.org/10.1111/j.1399-3011.1984.tb02690.x
Abstract
Synthesis of ostrich and turkey corticotropin (ACTH) has been accomplished by the solid‐phase method. Each was identical to the natural hormone in high performance liquid chromatography. Relative potencies in a lipolytic assay in isolated rabbit fat cells were: human ACTH, 100; ostrich ACTH, 53; turkey ACTH, 28. In isolated rat fat cells relative lipolytic potencies were: human ACTH, 100; ostrich ACTH, 2; turkey ACTH, 13. It was concluded that lipolytic potency is sensitive to alterations in structure throughout the entire length of the ACTH sequence in the rat fat cell assay.Keywords
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