Clinical, histologic, and cell kinetic discriminants between lamellar ichthyosis and nonbullous congenital ichthyosiform erythroderma
- 1 April 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 121 (4) , 489-493
- https://doi.org/10.1001/archderm.121.4.489
Abstract
Patients described as having lamellar ichthyosis (LI) may not all have the same disorder. Nine patients were studied, 4 of whom had erythroderma and generalized fine scaling, while the remainder had more marked scaling and hyperkeratosis without erythema. The former group is referred to as having nonbullous congenital ichthyosiform erythroderma (CIE),and the other is said to have LI. The clinical differences were paralleled by cell kinetic and histologic differences. The mean 3H thymidine autoradiographic labeling indices were 9.36 .+-. 4.05 and 19.70 .+-. 5.84 for the LI and CIE groups, respectively. The histologic differences were delineated using 10-cm analog scales and showed statistically significant differences for hyperkeratosis and parakeratosis. LI and CIE are separate disorders.Keywords
This publication has 1 reference indexed in Scilit:
- Ichthyosiform dermatoses. Classification based on anatomic and biometric observationsArchives of Dermatology, 1966