Stable isotopes of lithium: dissimilar biochemical and behavioral effects
- 1 September 1986
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 42 (9) , 985-987
- https://doi.org/10.1007/bf01940701
Abstract
Lithium, which is used routinely in the treatment of mania, is composed of two stable isotopes, lithium-7 (92.58%) and lithium-6 (7.42%). Usually there is minimal physiological or biochemical differentiation between isotopes of an element, but lithium is an exception. Data derived from a variety of biochemical and behavioral experiments are reviewed to support this idea. Additionally, the clinical implications of this work are presented.Keywords
This publication has 17 references indexed in Scilit:
- Erythrocyte differentiation of naturally occurring isotopic lithium abundancesPharmacology Biochemistry and Behavior, 1985
- Differential Uptake of Lithium Isotopes by Rat Cerebral Cortex and Its Effect on Inositol Phosphate MetabolismJournal of Neurochemistry, 1984
- Determination of lithium by optically monitored stable isotope dilutionAnalytical Chemistry, 1979
- Dissimilar effects of lithium isotopes on motility in ratsPharmacology Biochemistry and Behavior, 1979
- Lithium-6 stable isotope determination by atomic absorption spectroscopy and its application to pharmacokinetic studies in manJournal of Pharmacy and Pharmacology, 1978
- What happened later to the lithium babies? A FOLLOW‐UP STUDY OF CHILDREN BORN WITHOUT MALFORMATIONSActa Psychiatrica Scandinavica, 1976
- Detection of stable isotopes of lithium or boron with the help of a (n,α) nuclear reaction. Application to the use of 6Li as a tracer for unidirectional flux measurements and to the microlocalization of lithium in animal histologic preparationsBiochimica et Biophysica Acta (BBA) - General Subjects, 1976
- The International Register of Lithium BabiesDrug Information Journal, 1976
- The effect of prolonged lithium administration on activity, reactivity, and endurance in the ratPsychopharmacology, 1973
- Unit-cell dimensions of lithium fluoride made from Li6and Li7Acta Crystallographica, 1955