Lack of Carcinogenic Effects of Isonicotinic Acid Hydrazide in the Syrian Golden Hamsters

Open Access
Publisher Website
Google Scholar
Abstract
Isonicotinic acid hydrazide (INH) was administered as a 0.3 % solution for 42 weeks intermittently and as a 0.2 and 0.1 % solutions continuously in the drinking water for the lifespan of adult Syrian golden hamsters. 0.3 % INH solution was found to be too toxic, therefore it had to be given periodically and finally the treatment had to be stopped, while 0.2 and 0.1 % INH solutions were relatively well tolerated during the entire life of the animals. The consumption of INH resulted in no detectable tumorigenic effect in the treated hamsters. It is concluded that the drug is apparently no carcinogenic in this species. In view of the fact that the tumor producing capability of INH was shown by numerous studies in mice, the matter of selective neoplastic response in the various species is discussed and emphasized.