Reduction of soluble ICAM‐1 levels in nasal secretion by H1‐blockers in seasonal allergic rhinitis
- 1 October 1997
- Vol. 52 (10) , 1022-1025
- https://doi.org/10.1111/j.1398-9995.1997.tb02425.x
Abstract
ICAM‐1, a transmembrane glycoprotein promoting adhesion in immunologic and inflammatory reactions, was found to be increased on nasal epithelial cells of patients with allergic rhinitis. Loratadinae, an H1‐Mocker, was found to reduce in vitro the expression of ICAM‐1 on nasal epithelial cells. A double‐blind, parallel‐group study was carried out during the pollen season to compare the effect of two H1‐blockers, cetiraizine (10 mg OD) and loratadine (10 mg OD), on the release of soluble ICAM‐1 in nasal secretions. A group of untreated patients was used as a control group. sICAM‐1 was measured by enzyme immunoassay before and after 2 weeks of treatment. Symptoms were significantly decreased in the actively treated groups. sICAM‐1 levels were unchanged in the control group but were significantly reduced in the two treated groups (P1‐blockers, loratadine and cetirizinae, have a similar effect on sICAM‐1 released in nasal secretions during the pollen season.Keywords
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