Interleukin-1 and neuronal injury
Top Cited Papers
- 20 July 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 5 (8) , 629-640
- https://doi.org/10.1038/nri1664
Abstract
Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including activation of many inflammatory processes (through activation of T cells, for example), induction of expression of acute-phase proteins, an important function in neuroimmune responses and direct effects on the brain itself. There is now extensive evidence to support the direct involvement of interleukin-1 in the neuronal injury that occurs in both acute and chronic neurodegenerative disorders. This article discusses the key evidence of a role for interleukin-1 in acute neurodegeneration - for example, stroke and brain trauma - and provides a rationale for targeting the interleukin-1 system as a therapeutic strategy.Keywords
This publication has 109 references indexed in Scilit:
- Intra-parenchymal injection of tumor necrosis factor-? and interleukin 1-? produces dopamine neuron loss in the ratJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 2004
- Recommendations for Clinical Trial Evaluation of Acute Stroke TherapiesStroke, 2001
- Interleukin-1β exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice culturesNeuroscience Letters, 2001
- Increased IL-1β, IL-8, and IL-17 mRNA Expression in Blood Mononuclear Cells Observed in a Prospective Ischemic Stroke StudyStroke, 1999
- Dynamic regulation of the proinflammatory cytokine, interleukin-1β: Molecular biology for non-molecular biologistsLife Sciences, 1999
- Endogenous Interleukin-1 Receptor Antagonist is NeuroprotectiveBiochemical and Biophysical Research Communications, 1997
- Fever in Acute Stroke Worsens PrognosisStroke, 1995
- Early Intrathecal Production of Interleukin-6 Predicts the Size of Brain Lesion in StrokeStroke, 1995
- Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in RatsStroke, 1995
- A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytesNature, 1992