The effect of subcutaneous adrenaline and isoprenaline on the excretion of electrolytes by rats

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Abstract
Subcutaneous injections of 5 μg. (–) adrenaline and 0.25-0.6 μg. (±) isoprenaline/100 g. rat caused antidiuresis, retention of sodium and decreased excretion of potassium, without change either in filtration rate or in renal plasma flow. Denervation of the kidneys did not alter the effects of adrenaline, but enhanced the sodium retention caused by isoprenaline. This enhancement was accompanied by a small fall in filtration rate. The antidiuresis and sodium retention caused by isoprenaline was accompanied by retention of chloride and of water, decreased excretion of ammonia and potassium and a rise in urinary pH.

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