Biotransformation of cannabinoid precursors and related alcohols by suspension cultures of callus induced from Cannabis sativa L.

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Abstract
In suspension cultures using callus induced from C. sativa L., geraniol, nerol, olivetol and ethyl olivetolate, which are cannabinoid precursors, were not biotransformed to cannabinoids. Primary and secondary allylic alcohols such as geraniol, nerol, trans-cinnamyl alcohol, isophorol and trans-verbenol were biotransforned to the corresponding aldehydes. Acyclic secondary allylic alcohols such as .alpha.-ionol, .beta.-ionol and 4-phenyl-3-buten-2-ol were not biotransformed. The enzyme which catalyzed the oxidation of allylic alcohols was an alcohol oxidase.