Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α1B-glycoprotein
- 24 April 2009
- journal article
- research article
- Published by Wiley in Animal Genetics
- Vol. 18 (2) , 119-124
- https://doi.org/10.1111/j.1365-2052.1987.tb00750.x
Abstract
Pig, horse and dog plasma proteins, separated by horizontal polyacrylamide gel electrophoresis (pH 9.0) and electrophoretically transferred to nitrocellulose membranes, were tested for cross-reaction with antiserum to human plasma .alpha.1-B-glycoprotein (.alpha.1B). The results showed that one previously reported polymorphic plasma postalbumin in each of these species (pig PO2, horse Xk and dog Pa protein) was homologous to human plasma .alpha.1B. In the light of the previously known genetic linkages in these species, this implied: (1) .alpha.1B gene is close linked to Phi, Pgd and Hal (halothane sensitivity locus) loci in pigs; and (2) .alpha.1B gene is linked to ME1 and Phi locus in horses. This suggested that the .alpha.1B gene may also be found to be closely linked to gene(s) controlling susceptibility to malignant hyperthermia in humans and other mammals.Keywords
This publication has 20 references indexed in Scilit:
- Equine gene mapping: Close linkage between the loci for soluble malic enzyme and Xk (Pa)Animal Blood Groups and Biochemical Genetics, 2009
- Linkage between the porcine genes encoding immunoglobulin heavy‐chain allotypes and some serum α‐protease inhibitors: a conserved linkage in pig, mouse and humanAnimal Genetics, 1986
- Prediction of the halothane (Hal) genotypes of pigs by deducing Hal, Phi, Po2, Pgd haplotypes of parents and offspring: results from a large‐scale practice in Swedish breedsAnimal Blood Groups and Biochemical Genetics, 1985
- The halothane sensitivity locus and its linkage relationshipsAnimal Blood Groups and Biochemical Genetics, 1985
- Genetic linkage between the loci for phosphohexose isomerase (PHI) and a serum protein (Xk) in horsesAnimal Blood Groups and Biochemical Genetics, 1983
- Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry & Cytochemistry, 1981
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Identity of Xk and Pa systems in equine serumAnimal Blood Groups and Biochemical Genetics, 1978
- Genetic polymorphism of the vitamin D binding protein and another post‐albumin protein in horse serumAnimal Blood Groups and Biochemical Genetics, 1978
- Horizontal polyacrylamide gradient gel electrophoresis for the simultaneous phenotyping of transferrin, post‐transferrin, albumin and post‐albumin in the blood plasma of cattleAnimal Blood Groups and Biochemical Genetics, 1977