Electrogenerated Base-Induced N-Acylation of Chiral Oxazolidin-2-ones. 21
- 12 February 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (5) , 1719-1721
- https://doi.org/10.1021/jo016323a
Abstract
An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN−TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.Keywords
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