Studies of the C3 Shunt Activation in Cobra Venom Induced Lysis of Unsensitized Erythrocytes

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Abstract
A procedure is described to evaluate the activation of the C3 shunt through cobra venom factor-mediated lysis of unsensitized erythrocytes. Data pertaining to several parameters of this assay are given. These include the requirement for magnesium, inhibition by heparin and the effects of hydrazine. The available evidence also suggests that the mechanism of cobra venom interaction with serum factors such as C3 proactivator differs from that of immune aggregates or inulin.