A further prenatal diagnosis of mosaic tetrasomy 12p (Pallister‐Killian syndrome)

Abstract
A case of mosaic tetrasomy 12p was detected in amniotic fluid cell cultures from a 28‐year‐old woman referred to us at 26 weeks' gestation because of hydramnios. The fetus was shown on ultrasonography to have an omphalocele and a short femur length. Labour was induced at 32 weeks. An infant with multiple congenital anomalies was delivered and died after 10 min. The diagnosis of i(12p) or Pallister‐Killian syndrome was confirmed cytogenetically in fibroblast and lymphocyte cultures. Increased LDH‐B activity was demonstrated in fibroblasts.