Prolonged Biphasic Response of Plasma Testosterone to Single Intramuscular Injections of Human Chorionic Gonadotropin*

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Abstract
The response of plasma testosterone to varying doses of hCG [human chorionic gonadotropin] (0-6000 IU) given as a single i.m. injection was evaluated in normal men. After an initial rise at 2 h, the levels of testosterone demonstrated a secondary rise, reaching a peak 48 h after the i.m. injection. The magnitude of the response varied directly with the dose of hCG used, and at the highest dose (6000 IU) testosterone levels were still elevated 6 days after administration. Plasma estradiol levels showed a dose-dependent rise, with peak levels being attained 24 h after hCG. The prolonged response of plasma testosterone to a single hCG injection, should prompt a reevaluation of diagnostic and therapeutic regimens using this agent.

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