Molecular and chemical basis of prion-related diseases
- 1 January 1997
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 26 (6) , 425-432
- https://doi.org/10.1039/cs9972600425
Abstract
Prion-related diseases include scrapie in sheep, bovine spongiform encephalopathy in cattle and Creutzfeldt-Jakob disease in humans. The infectious agent for these diseases surprisingly contains no nucleic acid, but is a protein(PrP) which exists in two conformations, PrPC and PrPSc. The infectious PrPSc form has a higher β-sheet and lower α-helix content than PrPC. The structures of PrP and models for how PrPSc is able to replicate by converting PrPC to PrPSc are discussed.Keywords
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