Immunoelectron microscopic studies in IgA linear dermatosis
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 265 (3) , 289-298
- https://doi.org/10.1007/bf00412386
Abstract
The authors investigated three cases of IgA linear dermatosis by immunoelectron microscopy. In two of the cases there were additionally some IgG deposits in the basement membrane zone. The arrangement of the IgA deposits was found to vary. In two cases it was of the dermal and the lamina lucida type at the same time, and in one case it was so close to basal cell membranes as to leave an electronlucent space on the side facing the basal lamina. In the third case, the arrangement (only IgG and complement were studied) was exclusively of the dermal type. In one of the cases the deposits had first, i.e., 11/2 years earlier, been confined to the lamina lucida, whereas now they were also seen below the basal lamina, although the clinical condition of the patient had remained unchanged. It would seem that the localization of IgA deposits in the basement membrane zone may vary, depending on the evolution of the disease. In drei Fällen von IgA linear-Dermatosis wurden immunelektronenmikroskopische Untersuchungen durchgeführt. In zwei Fällen waren auch zusätzliche IgG-Ablagerungen in der Basalmembranzone vorhanden. Festgestellt wurde ein unterschiedlicher Charakter der IgA-Ablagerungen; in zwei Fällen waren sie gleichzeitig von dermalem und Lamina lucida-Typ, in einem von ihnen näher den Membranen der Basalzellen lokalisiert, so daß über der Lamina basalis ein elektronendurchsichtiger Raum entstand. Im dritten Fall waren die Ablagerungen (untersucht wurde nur IgG und Complement) ausschließlich von dermalem Typ. Es ist bemerkenswert, daß in einem früheren Fall, der durch Ablagerungen ausschließlich zunächst in der Lamina lucida charakterisiert war, nach 11/2 Jahren eine Ablagerung sowohl in der Lamina lucida als auch in der Lamina basalis sich einstellte, ohne daß das klinische Bild sich geändert hatte. Es ist möglich, daß die Lokalisation der IgA-Ablagerungen in der Basalmembranzone variabel und abhängig von der Evolution der Hautveränderungen ist.Keywords
This publication has 40 references indexed in Scilit:
- The Ultrastructural Localization of IgA in Skin of A Patient with Mixed Form of Dermatitis Herpetiformis and Bullous PemphigoidJournal of Investigative Dermatology, 1978
- The Pathogenesis of Dermatitis HerpetiformisJournal of Investigative Dermatology, 1978
- Circulating IgA Anti-Basement Membrane Zone Antibodies in Dermatitis HerpetiformisJournal of Investigative Dermatology, 1977
- Dermatitis Herpetiformis: Immunoelectronmicroscopic And Ultrastructural Studies Of A Patient With Linear Deposition Of IgaJournal of Investigative Dermatology, 1976
- DIAGNOSTIC SIGNIFICANCE OF THE IMMUNOFLUORESCENT PATTERN IN DERMATITIS HERPETIFORMISInternational Journal of Dermatology, 1975
- Ultrastructural Localization Of Immunoglobulins in Bullous Pemphigoid Skin. Employment of a New Peroxidase-Antiperoxidase Multistep MethodJournal of Investigative Dermatology, 1975
- Procedures for the Immunization of Goats with Human Immunoglobulins and ComplementInternational Archives of Allergy and Immunology, 1970
- Coupling of enzymes to proteins with glutaraldehydeImmunochemistry, 1969
- ELECTRON MICROSCOPIC STUDY OF DERMATITIS HERPETIFORMISBritish Journal of Dermatology, 1969
- THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966