Dimethyl sulphoxide: A review of its applications in cell biology
- 1 December 1994
- journal article
- review article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 14 (6) , 259-281
- https://doi.org/10.1007/bf01199051
Abstract
Dimethyl sulphoxide is a water miscible solvent that has wide applications in cell biology. It acts as a cryoprotective agent in a variety of cells and tissues allowing prolonged storage at subzero temperatures. The action of dimethyl sulphoxide on the stability of the liquid matrix of cell membranes appears to be responsible for its effects and this appears also to be true for related effects on membrane permeability and fusion. Dimethyl sulphoxide is also known to act as an inducer of cellular differentiation and as a free radical scavenger and radioprotectant. A review of the underlying molecular basis of all these effects of dimethyl sulphoxide is presented.Keywords
This publication has 79 references indexed in Scilit:
- What really cures in autologous bone marrow transplantation? A possible role for dimethylsulfoxideMedical Hypotheses, 1993
- The differentiation inducer, dimethyl sulfoxide, transiently increases the intracellular calcium ion concentration in various cell typesJournal of Cellular Physiology, 1993
- Effects of differentiation on the phospholipid and phospholipid fatty acid composition of N1E-115 neuroblastoma cellsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
- Giant sarcoplasmic reticulum vesicles: A study of membrane morphogenesisJournal of Muscle Research and Cell Motility, 1992
- Beware of proteins in DMSOBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
- Induction of umu gene expression in Salmonella typhimurium TA1535/pSK1002 by dimethyl sulfoxide (DMSO)Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1990
- Phospholipid membrane stabilization by dimethylsulfoxide and other inducers of friend leukemic cell differentiationBiochimica et Biophysica Acta (BBA) - Biomembranes, 1976
- EFFECTS OF DIMETHYL SULFOXIDE ON SUBUNIT PROTEINS*Annals of the New York Academy of Sciences, 1975
- Enthalpies of mixing of dimethylsulfoxide with water and with several ketones at 298.15 KThe Journal of Chemical Thermodynamics, 1971
- A POSSIBLE MECHANISM OF ACTION OF DMSO*Annals of the New York Academy of Sciences, 1967