Failure to Induce Tumors in Swiss Mice After Concurrent Administration of Amino Acids and Sodium Nitrite2
- 1 May 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 48 (5) , 1389-1392
- https://doi.org/10.1093/jnci/48.5.1389
Abstract
The effect of concurrent administration to Swiss mice of sodium nitrite (0.1%) with proline, hydroxyproline, or arginine (0.5%) in drinking water was investigated by use of the rapid quantitative lung-adenoma technique as a screening test. Nitrosoproline (0.05 and 0.1%), nitrosopiperidine (0.01%), and nitrosopyrrolidine (0.01%) were also tested. Lung adenomas did not increase with the amino acid/nitrite combinations or with nitrosoproline. Nitrosopiperidine (65 mg total dose/mouse), the positive control, caused tenfold more lung adenomas. Nitrosopyrrolidine (15 mg total dose/mouse) enhanced the number of lung adenomas, but was severely hepatotoxic. From the results of this screening bioassay, nitrosoproline probably is not carcinogenic. The concurrent administration of hydroxyproline or arginine together with 0.1% NaNO2 in the drinking water did not increase the lung adenoma frequency.Keywords
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