Achondroplasia and Parental Age
- 20 February 1986
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 314 (8) , 521-522
- https://doi.org/10.1056/nejm198602203140820
Abstract
To the Editor: Regulatory genes and the polygenic influences associated with quantitative variation have a critical role in the homeostatic control of development.1 2 3 In addition to coordinating the interacting steps in a developmental sequence, they help to buffer against unpredictable influences, such as nutritional limitations, minor teratogens, and mutations. Interference with their activity will reduce developmental homeostasis and can therefore increase the phenotypic variation and severity of genetic diseases. Here we report a condition in which increased parental age is associated with a change in the expression of an inherited condition.Achondroplasia4 is one of the best known examples of . . .Keywords
This publication has 4 references indexed in Scilit:
- SYNTHESIS: POLYGENIC VARIATION IN PERSPECTIVEPublished by Elsevier ,1979
- Achondroplasia—a genetic and statistical surveyAnnals of Human Genetics, 1970
- Assortative mating with respect to physical characteristicsEugenics Quarterly, 1968
- PARENTAL AGE AND MUTATIONThe Lancet, 1955