ACUTE CARDIOVASCULAR ALTERATIONS INDUCED BY LOW-DOSES OF ADRIAMYCIN, RUBIDAZONE, AND DAUNORUBICIN IN THE ANESTHETIZED BEAGLE DOG

  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (11-1) , 1771-1779
Abstract
I.v. injections of adriamycin (0.375-3.0 mg/kg), rubidazone (0.75-6.0 mg/kg) or daunorubicin (0.75-6.0 mg/kg) given within 1 min produced immediate hypotension in anesthetized beagle dogs. The threshold hypotensive dose for adriamycin (0.375 mg/kg, 7.5 mg/m2) was lower than that for rubidazone (0.75 mg/kg) or daunorubicin (1.5 mg/kg). Recovery from hypotension was more rapid after administration of rubidazone or daunorubicin than after adriamycin. Adriamycin (1.5-3.0 mg/kg) caused respiratory distress and depressed mean arterial pressure an average of 54-82% for up to 30 min. The hypotension was almost eliminated when the adriamycin (1.5 mg/kg) infusion period was extended to 15 min. Significant increases in plasma histamine concentrations, coinciding with the peak hypotensive response, were detected within 1 min after infusion of adriamycin (1.5 mg/kg) or rubidazone (1.5 mg/kg). Similar effects were noted after 6.0 mg/kg of daunorubicin. The acute cardiovascular effects of the 3 anthracycline compounds apparently were mediated through release of histamine.