NOREPINEPHRINE-SYNTHESIZING ENZYMES IN BRAIN, ADRENALS AND PERIPHERAL SYMPATHETIC NERVES OF SPONTANEOUSLY HYPERTENSIVE RATS

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Abstract
Dopamine-.beta.-hydroxylase (DBH) activity in the serum, DBH and tyrosine hydroxylase (TH) activities in the mesenteric vessels, and DBH and TH activities in the locus ceruleus and hypothalamus of brain did not differ significantly between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKR) at 16 wk of age when hypertension of SHR was fixed. DBH and TH activities in the vas deferens and adrenal glands were significantly higher in SHR than in WKR. These changes in SHR at 16 wk of age after the establishment of hypertension are directly opposite those reported previously in SHR at 3 wk of age before the onset of hypertension.