Effect of verapamil on contractility, oxygen utilization, and calcium exchangeability in mammalian heart muscle

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Abstract
The negative inotropic effect of verapamil is accompanied by a reduction in the myocardial demand for O2 and an improved efficiency. This negative inotropic effect is due neither to sympathetic blockade nor to an altered ability of the sarcoplasmic reticulum to accumulate, bind, or exchange Ca2+ . The capacity of membrane-located binding sites to accumulate Ca2+ is, however, impaired.