A polypeptide toxin from the coral Goniopora
- 7 July 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 202 (2) , 331-336
- https://doi.org/10.1016/0014-5793(86)80712-8
Abstract
A polypeptide toxin has been isolated from Goniopora coral with an M r of 19000. Goniopora toxin has the following properties: (i) it induces contraction of guinea pig ileum and this contraction is prevented by Ca2+‐channel blockers; (ii) it stimulates 45Ca2+ influx in cardiac cells in culture and this stimulation is abolished by Ca2+‐channel blockers; (iii) it prevents binding of (+)‐[3H]PN 200‐110 to the Ca2+‐channel protein of skeletal muscle T‐tubule membranes. All these results taken together suggest that Goniopora toxin is a Ca2+‐channel activator.Keywords
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