Prostaglandin E2 and the regulation of protein degradation in skeletal muscle
- 1 July 1987
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 10 (6) , 556-559
- https://doi.org/10.1002/mus.880100611
Abstract
We tested the influence of PGE2 on protein degradation in isolated mouse and rat muscles. PGE2 had no influence on protein degradation rate in mouse muscles under several different incubation conditions and over a dose range of 28 nM to 28 μM. Furthermore, neither PGE2 (2.8 μM) nor arachidonic acid (5 μM) influenced protein degradation in rat muscles under incubation conditions identical to those previously reported. The biological activity of our PGE2 was confirmed with the rat stomach fundic strip preparation. We question the contention that PGE2 regulates protein degradation in skeletal muscle.This publication has 13 references indexed in Scilit:
- Prostaglandin E2 and muscle protein turnover inPseudomonas aeruginosa sepsisBiochimica et Biophysica Acta (BBA) - General Subjects, 1985
- Systemic response to thermal injury in rats. Accelerated protein degradation and altered glucose utilization in muscle.Journal of Clinical Investigation, 1984
- Changes in prostaglandin release associated with inhibition of muscle protein synthesis by dexamethasoneBiochemical Journal, 1984
- The possible involvement of prostaglandin F2α in the stimulation of muscle protein synthesis by insulinBiochemical and Biophysical Research Communications, 1983
- The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit musclesBiochemical Journal, 1983
- Protein synthesis in isolated rabbit forelimb muscles. The possible role of metabolites of arachidonic acid in the response to intermittent stretchingBiochemical Journal, 1983
- Stimulation of Muscle Protein Degradation and Prostaglandin E2Release by Leukocytic Pyrogen (Interleukin-1)New England Journal of Medicine, 1983