cis- and trans-Platinum compounds of substituted pyrimidines and their products from thiourea in Kurnakov's reaction

1 March 1979

journal article
research article
Published by Canadian Science Publishing in Canadian Journal of Chemistry

Vol. 57 (5) , 526-529
https://doi.org/10.1139/v79-086

Abstract

Cis- and trans-[Pt(pm)2X2] (where pm = 2-aminopyrimidine, 4-phenylpyrimidine, 4-methyl-pyrimidine and X = Cl, Br) [potential antineoplastic drugs] were prepared and characterized. The cis compounds were isolated from the reaction of K2PtCl4 and pm in water, while trans-[Pt(pm)2X2] was obtained by isomerization of cis-[Pt(pm)2X2] in dimethylsulfoxide. The cis- and trans-isomers react with thiourea (tu) to give different products (Kurnakov''s test).

This publication has 1 reference indexed in Scilit:

Heavy transition metal complexes of biologically important molecules. I. The crystal and molecular structure of trans-dichloro(bis(isopropyl)-sulfoxide-S)(1-methylcytosine-N)platinum(II)
Canadian Journal of Chemistry, 1976