Synthesis and biological activity of 6-substituted mitosene analogs of the mitomycins
- 1 July 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 28 (7) , 921-926
- https://doi.org/10.1021/jm00145a013
Abstract
A series of 1-acetoxymitosene analogs, in which the substituent at C-6 was varied, was prepared by total synthesis and screened for activity against P388 leukemia in mice and induction of .lambda. phage in Escherichia coli. Among the 6-substituents prepared, none was as effective as the methyl group in conferring biological activity [1-acetoxy-7-methoxy-N-methylmitosene]. Certain N-methylcarbamates were more active than the unsubstituted carbamates.This publication has 5 references indexed in Scilit:
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