Stereoselectivity in the formation of mononuclear complexes of histidine and some bivalent metal ions

Abstract
The formation constants of complexes of Co2+, Ni2+, Cu2+, Zn2+, Pb2+, and [VO]2+ with D- and L-histidine have been measured at 25.0 °C and I= 0.10 mol dm–3(K[NO3]). The importance of protonated complexes in all the systems studied has been demonstrated and the structures of the various species are discussed. Thermodynamic stereoselectivity has been confirmed in the bis(histidinato)-complexes of Co2+, Ni2+, and Zn2+, and has been also found in the monoprotonated bis(histidine) complexes of Co2+, Ni2+, Cu2+, and Zn2+. Stereoselectivity as exhibited in the enthalpy change (ΔH) accompanying formation of bis(histidinato)cobalt(II) has been measured calorimetrically; ΔH for formation of the meso-bis complex is more favourable by 2.4 ± 0.2 kJ mol–1.

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