Familial Renal Hypouricemia with Intact Reabsorption of Uric Acid
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 45 (1) , 40-42
- https://doi.org/10.1159/000184069
Abstract
Three patients with renal hypouricemia in the same family are described. Serum urate levels in the mother were in the low normal range and were below normal in her 2 sons. In all 3 patients, the ratios of renal urate clearance to creatinine clearance were abnormally elevated. Clear responses to either pyrazinamide or probenecid administration were observed in these ratios. These results suggest that these 3 patients had renal hypouricemia with normal reabsorption of urate as judged by the criteria for differentiating abnormalities in renal urate handling. This corresponds to the previously postulated mechanism as renal urate hypersecretion. Possible limitations to the diagnostic use of probenecid and pyrazinamide are also discussed.Keywords
This publication has 3 references indexed in Scilit:
- Renal handling of urate in the syndrome of inappropriate secretion of antidiuretic hormoneArchives of internal medicine (1960), 1985
- Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.Journal of Clinical Investigation, 1985
- Hypouricemia due to an increment in renal tubular urate secretionArchives of internal medicine (1960), 1982