Natural history of acute septic arthritis in an avian model

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Abstract
An experimental model of acute septic arthritis is described, utilizing the injection of S. Aureus into chicken hock joints. The course of the infection was monitored over a 14-day period by measurement of chicken growth rate, histopathology of the joint, number of bacteria, and number and type of leukocytes in the synovial fluid. Bacterial numbers decreased initially then increased rapidly over the first 24 h. Leukocyte counts rose sharply, starting between 60 and 90 min after injection. Gross destruction of articular cartilage was observed at 4 days, and appeared to be initiated by the adherence of the staphylococci to the cartilage surface followed by their penetration and invasion of vascular tunnels in the epiphyseal cartilage. Extensive (but focal) erosion of the articular surface was evident by 14 days.

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