PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN LEVELS IN CHOLESTASIS OF PREGNANCY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (3) , 276-278
Abstract
Plasma concentrations of pregnancy specific .beta.-1-glycoprotein (PSBG) were measured by specific radioimmunoassay in 211 samples from 123 normal women during the 3rd trimester of pregnancy and in 166 samples from 68 patients with cholestasis of pregnancy. At 37-38 wk of gestation patients with cholestasis had significantly lower PSBG levels than the normal pregnant women (P < 0.005), whereas the levels in patients in the cholestasis were not significantly different from those for normal pregnant women before 37 wk. At 37-38 wk of gestation patients with cholestasis showed a slight correlation between placental weight and plasma PSBG levels (r = 0.362; P < 0.05), whereas this was not found in patients with normal pregnancy. No correlation was found between infant weight or length at birth and the PSBG concentrations in either group, and no difference was noted in PSBG concentrations between cases with and without fetal distress.

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