EFFECT OF CORTICOTROPHIN AND CORTISONE ON THE INCORPORATION OF 3H-THYMIDINE INTO THE DEOXYRIBONUCLEIC ACIDS (DNA) OF THE REGENERATING LIVER IN THE WHITE RAT

1 September 1968

journal article
Published by Bioscientifica in Acta Endocrinologica

Vol. 59 (1) , 10-22
https://doi.org/10.1530/acta.0.0590010

Abstract

Both cortisone and ACTH inhibit the incorporation of ³H-thymidine into the DNA of parenchymatous cells in the regenerating rat liver. In addition, the mitotic activity of hepatocytes is markedly impaired. It is assumed that the suppression of mitoses in the regenerating rat liver, caused by cortisone or ACTH, is due to a direct or indirect interference with DNA synthesis.

Keywords

HEPATOCYTES
CORTISONE
WHITE
THYMIDINE
INDIRECT
MITOSES
MITOTIC
DEOXYRIBONUCLEIC
MARKEDLY

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