Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.
Open Access
- 1 April 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (4) , 1794-1798
- https://doi.org/10.1128/mcb.9.4.1794
Abstract
We report that the genes for the homologous Saccharomyces cerevisiae RAD10 and human ERCC-1 DNA excision repair proteins harbor overlapping antisense transcription units in their 3' regions. Since naturally occurring antisense transcription is rare in S. cerevisiae and humans (this is the first example in human cells), our findings indicate that antisense transcription in the ERCC-1-RAD10 gene regions represents an evolutionarily conserved feature.Keywords
This publication has 30 references indexed in Scilit:
- Two Mammalian Genes Transcribed from Opposite Strands of the Same DNA LocusScience, 1987
- Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair geneCell, 1986
- Gene within a gene: Nested Drosophila genes encode unrelated proteins on opposite DNA strandsCell, 1986
- Phenocopy of discoidin I-minus mutants by antisense transformation in DictyosteliumCell, 1985
- Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNACell, 1985
- Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNAScience, 1985
- Production of phenocopies by Krüppel antisense RNA injection into Drosophila embryosNature, 1985
- Molecular cloning of the RAD10 gene of Saccharomyces cerevisiaeGene, 1985
- Inhibition of thymidine kinase gene expression by anti-sense RNA: A molecular approach to genetic analysisCell, 1984
- Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencingJournal of Molecular Biology, 1980