Apoptosis Induced byStaphylococcus aureusin Epithelial Cells Utilizes a Mechanism Involving Caspases 8 and 3
- 1 May 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (5) , 2998-3001
- https://doi.org/10.1128/iai.68.5.2998-3001.2000
Abstract
In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.Keywords
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