Abdominal Pain after Taking Ursodiol

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Abstract
Ursodiol has been approved by the Food and Drug Administration for the dissolution of gallstones, but it is also widely used to treat chronic cholestatic liver diseases, such as primary biliary cirrhosis and sclerosing cholangitis1-4. Despite increasing experience with this medication, there have been remarkably few adverse reactions noted. We report two patients in whom severe right-upper-quadrant pain developed on repeated occasions within hours after taking ursodiol.