Polyhalogenoheterocyclic compounds. Part XXVI. Nucleophilic substitution in trifluoropyrazines
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2580-2584
- https://doi.org/10.1039/p19740002580
Abstract
The orientation of substitution in trifluoropyrazines C4N2F3X (X = H, Cl, Br, OMe, or NMe2) by methoxide and dimethylamine is described. Further attack para to H, Cl, or Br and ortho to OMe occurs; attack ortho to Me2N is observed when steric factors permit. The synthesis of perfluorobipyrazin-2-yl is reported.Keywords
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