Haematopoietic role for Patch (Ph) revealed by newWmutant (Wct) in mice

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Abstract
SUMMARY: A new mutant (Wct) has been identified at theWlocus of the mouse. The homozygote is poorly viable. Whereas the heterozygote (Wct/ +) is only mildly anaemic likeWυ/ +, the double heterozygoteWct+ / +Phis considerably more anaemic thanWυ+ / +Phand it andWsh+ / +Phhave significantly raised leucocyte counts.Wct+ / +Phis also unduly radiosensitive to whole body X-irradiation, 50% dying from haematopoietic failure at a dose of 4·59 ± 0·14 Gy, whereas the median forWct/ + was 6·49 ± 0·28 Gy. Serial blood counts of mice after low- or sub-lethal doses of X-rays revealed significantly more profound depression of counts of both red cells and leucocytes inWct+, and more notably inWct+ / +Ph, than in + / + orWsh/ + (haematologically normal) iso-dosed mice. We conclude that control of haematopoiesis by chromosome 5 is not confined to theWlocus but is shared by the linked genePh(and perhapsRw) and that expression of the change is not limited to the erythron but involves the pluripotent haematopoietic stem cell.

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