Morphea-like reaction to D-penicillamine therapy.

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Abstract
The case of a 48 yr old woman who developed morphea-like plaques after 1 yr of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type is reported. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 mo. The histological appearance was of increased dermal fibrosis with an inflammatory infiltrate round dermal capillaries. Epidermal changes were not typical of morphea. New lesions ceased to appear within a few months of stopping penicillamine, and by 1 yr all the plaques were pale and symptomless.