Lessons from human progeroid syndromes
- 1 November 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 408 (6809) , 263-266
- https://doi.org/10.1038/35041705
Abstract
A number of human genes have been identified in which mutations can lead to the accelerated emergence of features of senescence. Studies of these genes, and of the functions of their protein products, may lead to a clearer understanding of the nature of senescence, and could provide clues for ways in which ageing might be retarded.Keywords
This publication has 50 references indexed in Scilit:
- Functional Interaction between Ku and the Werner Syndrome Protein in DNA End ProcessingJournal of Biological Chemistry, 2000
- Spontaneous mutation in manMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999
- Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese populationAmerican Journal of Medical Genetics, 1997
- Generalized lipodystrophy, congenital and acquired (lipoatrophy)Acta Paediatrica, 1996
- Genetic analysis of ageing: role of oxidative damage and environmental stressesNature Genetics, 1996
- Nijmegen breakage syndrome.Journal of Medical Genetics, 1996
- Somatic Mutations Are Frequent and Increase with Age in Human Kidney Epithelial CellsHuman Molecular Genetics, 1996
- Role of Glycation in AgingAnnals of the New York Academy of Sciences, 1992
- Rothmund-Thomson syndrome: Review of the world literatureJournal of the American Academy of Dermatology, 1992
- In vivo human somatic mutation: frequency and spectrum with ageMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1992