Synthesis of Hydrazides Through an Enzymatic Hydrazinolysis Reaction
- 1 January 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1991 (05) , 350-352
- https://doi.org/10.1055/s-1991-26462
Abstract
Amano PS lipase catalyzes the reaction of formic hydrazide, acetic hydrazide and methyl carbazate with various esters: α, β-unsaturated hydrazides were obtained by using methyl acrylate or vinyl crotonate. The reaction with ethyl (±)-2-chloropropionate yields the corresponding hydrazide in good yield but with moderate enantiomeric excess.Keywords
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