Long-Lasting Neural and Behavioral Effects of Iron Deficiency in Infancy
Top Cited Papers
- 1 May 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 64 (5) , 34-43
- https://doi.org/10.1301/nr.2006.may.s34-s43
Abstract
Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.Keywords
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