EXPERIMENTAL PRODUCTION OF FOCAL EPILEPSY

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Abstract
By means of chemical and immunologic agents, Kopeloff, Barrera and Kopeloff1 produced in the monkey chronic recurrent convulsive seizures of the jacksonian and the generalized type. This was accomplished by exposing the cerebral motor cortex of the anesthetized monkey and inserting a small, round, laminated, compressed linen disk with a depression on one side containing an "effective substance" in such a manner as to maintain direct contact between this substance and the cortex. The meninges were sutured firmly over the disk to hold it in place, and the incision in the scalp was then closed by means of clips. In most of the animals in which seizures developed the attacks were first noted approximately three to eight weeks after operation. PRESENT INVESTIGATION Material and Methods. —In this communication we are reporting electroencephalographic observations on 5 monkeys, each weighing 3 to 4 kilograms, in which recurrent jacksonian seizures developed as

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