REPRESSION OF ALKALINE PHOSPHATASE IN HUMAN CELL CULTURES BY CYSTINE AND CYSTEINE

1 April 1963

journal article
research article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 49 (4) , 504-510
https://doi.org/10.1073/pnas.49.4.504

Abstract

Alkaline phosphatase of certain established human cell cultures is repressed by cyst(e)ine, a constituent of the usual growth media. Forty hours are required for substantial cyst(e)ine-mediated repression of alkaline phosphatase. The observations described suggest that repression is caused by interference with enzyme synthesis or activation rather than sulfhydryl inhibition of alkaline phosphatase activity.

Keywords

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