Identification of high levels of protein phosphatase‐1 in rat liver nuclei

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Abstract
Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase‐1 in its molecular mass, sensitivity to inhibitor‐1 and inhibitor‐2 and specificity for the β‐subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase‐1 activity in nuclei is at least 5‐fold higher than its average extranuclear concentration.