TOXICITY OF SPIROGERMANIUM IN MICE AND DOGS AFTER IV OR IM ADMINISTRATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 64  (12) , 1207-1210
Abstract
Toxicity of single-dose spirogermanium was evaluated after i.v. and i.m. administration of CDF1 mice and beagle dogs. The i.m. LD50 in mice was approximately 3-fold greater than the i.v. LD50. The lethal dose in dogs was the same for both routes of administration; death was delayed after i.m. injection. Convulsive seizures occurred only after the i.m. doses that were lethal, but they were observed after administration of i.v. doses that were nonlethal. Microscopic evidence of drug toxicity (necrosis and degeneration) was found in the following mitotically active tissues: intestinal tract, lymphoid tissue and bone marrow. Necrosis, hemorrhage, edema and granulation tissue were observed in the muscle injection site.

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