On the Meaning of Vesiculation in Capillary Endothelium

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Abstract
Electron microscope observations support the hypothesis that vesiculation is involved in the dynamics of surface membranes of capillary endothelium. So vesiculation may form and remove endothelial pores, gaps, microvilli, and basal feet. It takes part in changes of the overlapping at intercellular contacts and of the diameter of capillaries. Observations and calculations are discussed which contradict a directed transport of substances within vesicles. Vesiculation is an expression of membrane dynamics which is related to vascular permeability.

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