Simple Construction of Neu5Ac(α2-8)Neu5Ac and Total Synthesis of Ganglioside GD3
- 1 September 1996
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 15 (7) , 857-878
- https://doi.org/10.1080/07328309608005696
Abstract
Glycosylation of an 8-unprotected sialyl fluoride 16 with 2β-chloro-3β-phenylthio-Neu5Ac 2 gave the desired α-disialate 23. Subsequent glycosylation of a thiolactoside 19 with the disialyl fluoride 23 gave the tetrasaccharide 28. Synthesis of GD3 1 was realized by condensation of the tetrasaccharide 28 with azidosphingosine 31, following our previously reported GM3 synthesis procedure.Keywords
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