Some Pharmacological Characteristics of Bacitracin II. Absorption and Excretion of Bacitracin in the Dog.

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Abstract
Only small fractions of the oral dose were recovered in the stool. Since none was found in the blood or urine after oral admn. and little was found in the feces, it appears that the antibiotic was largely destroyed in the gastro-intestinal tract. Following parenteral admn. of large single doses, significant concs. of the drug persisted in the blood stream for as long as 7 or 8 hrs. Other than slight and transient central effects produced by excessively rapid intraven. injn., the animals showed no apparent signs of toxicity in spite of the fact that doses as high as 6000 units/kg. body wt. were administered. The recovery of the drug in the urine appeared, in general, to increase in direct ratio to the dose administered, but the recoveries were widely variable. Significant concs. of bacitracin persisted in the urine for more than 7 hrs. after admn. of a single dose. Bacitracin is not freely diffusible. It did not penetrate the red blood cell, nor did it enter the spinal fluid freely.
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