Antibiotic Resistance of Indole-Positive Klebsiella pneumoniae

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Abstract
Resistance patterns to antibiotics differed markedly between indole-positive and indole-negative K. pneumoniae strains. Multiple-drug-resistant strains were almost exclusively indole-negative. Ampicillin and kanamycin resistances in the indole-positive strains tested were not transmissible, while many of those resistances in the indole-negative strains were transmissible, together with other drug resistances to an Escherichia coli recipient. The substrate profile of the .beta.-lactamase from the indole-positive strains was fairly different from that of the .beta.-lactamase mediated by the ampicillin resistance plasmid.