BLASTOGENIC RESPONSE OF PURIFIED HUMAN T-LYMPHOCYTE POPULATIONS TO EPSTEIN-BARR VIRUS (EBV)

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 30  (3) , 347-353
Abstract
The blastogenic response of T[thymus-derived]cell populations to infectious EBV (B95-8 strain) was studied. The addition of virus increased the [3H]thymidine uptake of unfractionated lymphocytes from seropositive and seronegative subjects, and from cord blood, but not from patients with infectious mononucleosis. The same amount of virus evoked a small response in purified T cells from seropositive donors, but not in T cells from the other sources. The addition of autologous B [bone marrow-derived] lymphocytes with EBV adsorbed on their surfaces caused a more significant blastogenic response, which was even more pronounced in the presence of mercaptoethanol.