Multiple effects induced by unstable mutation in Streptomyces lavendulae.

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Abstract
Arg mutants, isolated from S. lavendulae at unusually high frequencies, showed several phenotypic characteristics. The characteristics common to all arg mutants include: repression of .beta.-lactamase production, inhibition of aerial mycelium formation, development of acid pH, low saturation density of growth in liquid culture, a decrease in antibiotic production, an increase in sensitivity to benzylpenicillin and a decrease in production of pigment. These results suggest that the arg mutation concomitantly caused the depression of secondary metabolism in S. lavendulae.